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Summary: Insects that are exposed to insecticides will eventually develop resistance. This presentation focuses on general management strategies that can be taken once resistance develops. While the management strategies are general, the presentation focuses on three case studies in cotton, to help with specific application of the principles: bollworm, tarnished plant bug, and tobacco thrips. These three cases, which represent examples of insecticide resistance in southeastern US cotton are contrasted with the very successful example of insecticide resistance management for whiteflies in Arizona cotton for applicability across the US Cotton Belt. After this presentation consultants, county agents, growers and scouts should be more familiar with how to define resistance and the strategies that can be used to mitigate resistance.